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AMG-208

AMG-208

Item no.	V0599-5mg
Manufacturer	InvivoChem LLC
CASRN	1002304-34-8
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1002304-34-8
Available
Description	InvivoChem Cat #:V0599CAS #:1002304-34-8Purity >=98% Description: AMG 208 (AMG-208) is a novel, highly potent and selective triazolopyridazine-based small molecule inhibitor of c-Met with potential antineoplastic activity. It inhibits c-Met with IC50 of 9 nM. MET is an oncogene activated by its ligand, hepatocyte growth factor. Deregulated/disrupted c-Met signaling pathway hasbeen observed in multiple cancer types. Description: References: J Med Chem. 2008 May 22; 51(10):2879-82; Bioorg Med Chem Lett. 2009 Nov 15; 19(22):6307-12. References:
Molecular Weight (MW)	383.4
Formula	C22H17N5O2
CAS No.	1002304-34-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 0.25 mg/mL (0.65 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
Synonyms	AMG 208; AMG-208; AMG208; 4-[(6-phenyl-[1, 2, 4]triazolo[4, 3-b]pyridazin-3-yl)methoxy]-7-methoxyquinoline InChi Key: HEAIZQNMNCHNFD-UHFFFAOYSA-N InChi Code: InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H, 14H2, 1H3 SMILES Code: COC1=CC=C2C(OCC3=NN=C4C=CC(C5=CC=CC=C5)=NN43)=CC=NC2=C1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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