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Bemcentinib (R428; BGB-324; R-428)

Bemcentinib (R428; BGB-324; R-428)

Item no.	V0635-5mg
Manufacturer	InvivoChem LLC
CASRN	1037624-75-1
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1037624-75-1
Available
Description	InvivoChem Cat #:V0635CAS #:1037624-75-1Purity >=98% Description: Bemcentinib (formerly known as BGB324; R428) is a novel, potent and selective inhibitor of the RTK (receptor tyrosine kinase) Axl with potential anticancer activity. It inhibits Axl with an IC50 of 14 nM, and shows > 100-fold higher selectivity for Axl over Abl. R428 showed high activity in blocking tumor spread and prolonging survival in animal models with metastatic breast cancer. Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade by R428 confers therapeutic value in prolonging survival of animals bearing metastatic tumors. Description References: Cancer Res. 2010 Feb 15; 70(4):1544-54; Blood. 2011 Feb 10; 117(6):1928-37. References: Related CAS: 1037624-91-1 (racemic); 1037624-75-1;
Molecular Weight (MW)	506.64
Formula	C30H34N8
CAS No.	1037624-75-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 6 mg/mL (11.8 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	5% DMSO+corn oil: 1 mg/mL
Chemical Name	(S)-1-(6, 7-dihydro-5H-benzo[6, 7]cyclohepta[1, 2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6, 7, 8, 9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1, 2, 4-triazole-3, 5-diamine Exact Mass: 506.29064
SMILES Code	NC1=NC(NC2=CC=C3C(CC[CH](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5
Synonyms	BGB-324; R428; Bemcentinib; R 428; R-428; BGB324; BGB 324;

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Amount: 5 mg

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Delivery expected until 10/2/2025

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