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GW441756

GW441756

Item no.	V0640-10mg
Manufacturer	InvivoChem LLC
CASRN	504433-23-2
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	504433-23-2
Available
Description	InvivoChem Cat #:V0640CAS #:504433-23-2Purity >=98% Description: GW441756 (GW-441756) is a novel, potent and selective inhibitor of TrkA (Tropomyosin-related kinase A) with potential anticancer activity. It inhibits TrkA with an IC50 of 2 nM, and shows no/little activity against c-Raf1 and CDK2. The activity of TrkA kinase can affect its downstream signaling and involves in many biological processes including proliferation, differentiation and apoptosis. GW 441756 exhibits excellent anti-proliferative activity in human muscle sarcoma cancer cell line HTB114, and treatment of GW441756 dose-dependently suppressed the proliferation and induced apoptosis. Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma. Description: References: Bioorg Med Chem Lett. 2004 Feb 23; 14(4):953-7; Exp Mol Med. 2008 Jun 30; 40(3): 276–285; Mol Cells. 2008 Jul 31; 26(1):12-7. References
Molecular Weight (MW)	275.3
Formula	C17H13N3O
CAS No.	504433-23-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 25 mg/mL (90.8 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 1, 3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3, 2-b]pyridin-2-one InChi Key: NXNQLECPAXXYTR-LCYFTJDESA-N InChi Code: InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H, 1H3, (H, 19, 21)/b13-9- SMILES Code: O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4
Synonyms	GW 441756; GW441756; GW-441756

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Amount: 10 mg

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Delivery expected until 9/4/2025

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