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spebrutinib-cc-292-avl-292

spebrutinib-cc-292-avl-292

Item no.	V0644-10mg
Manufacturer	InvivoChem LLC
CASRN	1202757-89-8
Amount	10mg
Category	Oncology Neuroscience Neuroinflammation By Cell Type Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1202757-89-8
Available
Description	InvivoChem Cat #:V0644CAS #:1202757-89-8Purity >=98% Description: Spebrutinib (formerly AVL-292; CC-292; SBT) is a covalent/irreversible, orally bioactive, and highly selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase/BTK inhibitor with potential antitumor activity. It inhibits BTK with an IC50 of< 0.5 nM, and exhibits > 1400-fold higher selectivity for BTK over the other kinases. Description: References: J Pharmacol Exp Ther. 2013 Aug; 346(2):219-28; Br J Haematol. 2013 Nov; 163(4):436-43. References: Related CAS #: 1360053-81-1 (Spebrutinib besylate)
Molecular Weight (MW)	423.44
Formula	C22H22FN5O3
CAS No.	1202757-89-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 85 mg/mL (200.7 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide InChi Key: KXBDTLQSDKGAEB-UHFFFAOYSA-N InChi Code: InChI=1S/C22H22FN5O3/c1-3-20(29)25-16-5-4-6-17(13-16)26-21-19(23)14-24-22(28-21)27-15-7-9-18(10-8-15)31-12-11-30-2/h3-10, 13-14H, 1, 11-12H2, 2H3, (H, 25, 29)(H2, 24, 26, 27, 28) SMILES Code: C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(OCCOC)C=C3)=NC=C2F)=C1)=O
Synonyms	Spebrutinib; CC-292; AVL292; AVL-292; CC292; CC 292; AVL 292;

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Amount: 10mg

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Delivery expected until 7/3/2025

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