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LFM-A13

LFM-A13

Item no.	V0647-10mg
Manufacturer	InvivoChem LLC
CASRN	244240-24-2
Amount	10 mg
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg 50 mg
Category	Oncology By Cell Type Hematology Leukemia Lymphoma Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	244240-24-2
Available
Description	InvivoChem Cat #:V0647CAS #:244240-24-2Purity >=98% Description: LFM-A13 (LFM-A1-3) is a novel, potent and specific Bruton's tyrosine kinase (BTK) inhibitor with potential anticancer activity. It inhibits BTK with an IC50 of 2.5 uM, and shows > 100-fold selectivity over other protein kinases such as JAK1, JAK2, HCK, EGFR, and IRK. LFM-A13 inhibited recombinant BTK expressed in a baculovirus expression vector system. Besides its remarkable potency in BTK kinase assays, LFM-A13 was also found to be a highly specific inhibitor of Polo-like kinases. LFM-A13 shows high in vivo anticancer efficacy in BALB/c mice bearing BCL-1 leukemia. Description:n BALB/c mice bearing BCL-1 leukemia References: J Biol Chem. 1999 Apr 2; 274(14):9587-99; Clin Cancer Res. 2002 May; 8(5):1224-33; Am J Hematol. 2013 Jun; 88(6):463-71. References:
Molecular Weight (MW)	360
Formula	C11H8Br2N2O2
CAS No.	244240-24-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 72 mg/mL (200.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 2-Cyano-N-(2, 5-dibromophenyl)-3-hydroxy-2-butenamide InChi Key: UVSVTDVJQAJIFG-VURMDHGXSA-N InChi Code: InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4, 16H, 1H3, (H, 15, 17)/b8-6- SMILES Code: C/C(O)=C(C#N)/C(NC1=CC(Br)=CC=C1Br)=O
Synonyms	LFM-A13; LFM A13; LFM A13

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 10/2/2025

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