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PF-431396

PF-431396

Item no.	V0661-10mg
Manufacturer	InvivoChem LLC
CASRN	717906-29-1
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	717906-29-1
Available
Description	InvivoChem Cat #:V0661CAS #:717906-29-1Purity >=98% Description: PF-431396 (PF431396) is a pyrimidine-based and selective dual inhibitor of PYK2 and FAK (focal adhesion kinase and proline-rich tyrosine kinase 2) with potential anti-osteoporotic activity. It inhibits PYK2/FAK with IC50s of 11 nM and 2 nM, respectively. PF 431396 acts by promoting osteoblast recruitment and activity, thus stimulating bone formation in ovariectomized rats. PF-431396 can be potentially used in treatment of osteoporosis. Description: References: J Biol Chem. 2009 May 8; 284(19):13193-201; J Biol Chem. 2009 Aug 21; 284(34):22865-77. References
Molecular Weight (MW)	506.5
Formula	C22H21F3N6O3S
CAS No.	717906-29-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (197.43 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-Methyl-N-[2-[[[2-[(2, 3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide InChi Key: POJZIZBONPAWIV-UHFFFAOYSA-N InChi Code: InChI=1S/C22H21F3N6O3S/c1-31(35(2, 33)34)18-6-4-3-5-13(18)11-26-20-16(22(23, 24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9, 12H, 10-11H2, 1-2H3, (H, 29, 32)(H2, 26, 27, 28, 30) SMILES Code: CS(=O)(N(C)C1=CC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O
Synonyms	PF 431396; PF431396; PF-431396;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 10/2/2025

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