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cilomilast

cilomilast

Manufacturer	InvivoChem LLC
Category	Food Safety Drugs Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	25mg
Item no.	V0779-25mg
CASRN	153259-65-5
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V0779CAS #:153259-65-5Purity >=98% Description: Cilomilast (also known as SB-207, 499; SB207499; trade name Ariflo) is a novel, potent and orally bioactive phosphodiesterase 4/PDE4 inhibitor with potential anti-inflammatory and immunomodulatory activity. It inhibits PDE4 with an IC50 of ca.110 nM, it has anti-inflammatory activity and low central nervous system activity. It has the potential to be used for the treatment of asthma and chronic obstructive obstructive pulmonary (COPD). Description: References: J Pharmacol Exp Ther. 1998 Nov; 287(2):705-11; Int Immunopharmacol. 2011 Jun; 11(6):732-9. References:
Molecular Weight (MW)	343.42
Formula	C20H25NO4
CAS No.	153259-65-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 69 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol: 50 mg/mL (145.6 mM)
Solubility (In vivo)	5% DMSO+95% Corn oil: 30 mg/mL
Synonyms	Cilomilast; SB 207499; SB207499; Ariflo; SB-207499; Chemical Name: cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid InChi Key: CFBUZOUXXHZCFB-LDTOLXSISA-N InChi Code: InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7, 12, 14, 16H, 2-5, 8-11H2, 1H3, (H, 22, 23)/t14-, 20+ SMILES Code: O=C([CH]1CC[C](C2=CC=C(OC)C(OC3CCCC3)=C2)(C#N)CC1)O

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Amount: 25mg

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Delivery expected until 7/4/2024