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pemetrexed-disodium-hydrate

pemetrexed-disodium-hydrate

Item no.	V0851-250mg
Manufacturer	InvivoChem LLC
CASRN	357166-30-4
Amount	250 mg
Quantity options	100 mg 10 g 1 g 2 g 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	357166-30-4
Available
Description	InvivoChem Cat #:V0851CAS #:357166-30-4Purity >=98% Description: Pemetrexed Disodium Hydrate (LY-231514; HSDB-7316; trade name Alimta), the hydrated disodium salt of Pemetrexed which is a synthetic pyrimidine-based antifolate, is a novel antifolate and antimetabolite anticancer drug targeting TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed exhibits high autitumor activity in a broad range of tumors such as NSCLC/non-small cell lung carcinoma, malignant mesothelioma, and carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder. Description: References: Cancer Res. 1997 Mar 15; 57(6):1116-23; Clin Cancer Res. 2000 Mar; 6(3):1016-23. References: Related CAS: 137281-23-3 (free acid); 357166-30-4 (sodium 2.5 hydrate); 357166-29-1 (sodium hydrate); 150399-23-8 (disodium); 1851348-04-3 (pemetrexed tromethamine)
Molecular Weight (MW)	516.42
Formula	C20H21N5O6.5/2H2O.2Na
CAS No.	357166-30-4 (sodium 2.5 hydrate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (193.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: sodium (S)-2-(4-(2-(2-amino-4-oxo-4, 7-dihydro-1H-pyrrolo[2, 3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate heptahydrate. InChi Key: QJVSMHJWAOSBMD-MYXYZBIASA-L InChi Code: InChI=1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27; ; ; ; ; ; ; ; ; /h1-2, 4-5, 9, 13H, 3, 6-8H2, (H, 23, 28)(H, 26, 27)(H, 30, 31)(H4, 21, 22, 24, 25, 29); ; ; 71H2/q; 2+1; ; ; ; ; ; ; /p-2/t13-; ; ; ; ; ; ; ; ; /m0........./s1 SMILES Code: O=C([O-])[CH](NC(C1=CC=C(CCC2=CNC(NC(N)=N3)=C2C3=O)C=C1)=O)CCC([O-])=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]
Synonyms	LY-231514 Disodium Hydrate; LY231514; LY 231514; Pemetrexed, US brand name: ALIMTA

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Amount: 250 mg

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