« Back
Home /
LY2119620

LY2119620

Item no.	V1165-2mg
Manufacturer	InvivoChem LLC
CASRN	886047-22-9
Amount	2 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	886047-22-9
Available
Description	InvivoChem Cat #:V1165CAS #:886047-22-9Purity >=98% Description: LY2119620 (LY 2119620; LY-2119620) is a novel, potent, specific, high-affinity and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors, the so called positive allosteric modulator (PAM). LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. In 35SGTPgammaS-binding experiments, LY2119620 exhibited a modest allosteric agonism of 23.2% and 16.8% at the M2 and M4 receptors, respectively. LY2119620 and ACh binding caused cooperativity factor alpha of 79.4 and 19.5 for the M4 receptor and the M2 receptor, respectively. Description: References: Mol Pharmacol. 2014 Jul; 86(1):106-15; Mol Pharmacol. 2014 Jul; 86(1):116-23. References:
Molecular Weight (MW)	437.94
Formula	C19H24ClN5O3S
CAS No.	886047-22-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 87 mg/mL (198.7 mM)
	Water: < 1 mg/mL
	Ethanol: 10 mg/mL(22.8 mM)
Other info	Chemical Name: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2, 3-b]pyridine-2-carboxamide InChi Key: TYTGOXSAAQWLPJ-UHFFFAOYSA-N InChi Code: InChI=1S/C19H24ClN5O3S/c1-10-13-15(21)16(17(27)22-11-3-4-11)29-19(13)23-18(14(10)20)28-9-12(26)25-7-5-24(2)6-8-25/h11H, 3-9, 21H2, 1-2H3, (H, 22, 27) SMILES Code: O=C(C1=C(N)C2=C(C)C(Cl)=C(OCC(N3CCN(C)CC3)=O)N=C2S1)NC4CC4
Synonyms	LY2119620; LY 2119620; LY-2119620

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 2 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 14 days

Compare

Add to wishlist

Get an offer