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LY2119620

LY2119620

Item no.	V1165-250mg
Manufacturer	InvivoChem LLC
CASRN	886047-22-9
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1165CAS #:886047-22-9Purity >=98% Description: LY2119620 (LY 2119620; LY-2119620) is a novel, potent, specific, high-affinity and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors, the so called positive allosteric modulator (PAM). LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. In 35SGTPgammaS-binding experiments, LY2119620 exhibited a modest allosteric agonism of 23.2% and 16.8% at the M2 and M4 receptors, respectively. LY2119620 and ACh binding caused cooperativity factor alpha of 79.4 and 19.5 for the M4 receptor and the M2 receptor, respectively. Description: References: Mol Pharmacol. 2014 Jul; 86(1):106-15; Mol Pharmacol. 2014 Jul; 86(1):116-23. References:
Molecular Weight (MW)	437.94
Formula	C19H24ClN5O3S
CAS No.	886047-22-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 87 mg/mL (198.7 mM)
	Water: < 1 mg/mL
	Ethanol: 10 mg/mL(22.8 mM)
Other info	Chemical Name: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2, 3-b]pyridine-2-carboxamide InChi Key: TYTGOXSAAQWLPJ-UHFFFAOYSA-N InChi Code: InChI=1S/C19H24ClN5O3S/c1-10-13-15(21)16(17(27)22-11-3-4-11)29-19(13)23-18(14(10)20)28-9-12(26)25-7-5-24(2)6-8-25/h11H, 3-9, 21H2, 1-2H3, (H, 22, 27) SMILES Code: O=C(C1=C(N)C2=C(C)C(Cl)=C(OCC(N3CCN(C)CC3)=O)N=C2S1)NC4CC4
Synonyms	LY2119620; LY 2119620; LY-2119620

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Amount: 250 mg

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Delivery expected until 11/6/2025

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