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Description: Wogonin (Vogonin), a naturally occurring and pharmacologically-active flavonoid found in plants, has been reported to exhibit anticancer effects against various cancer cell types such as osteosarcoma, leukemia, breast cancer and glioma. Wogonin induced a G1 phase cell cycle arrest in HCT116 cells in a concentration- and time-dependent manner. Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest. Furthermore, we showed that the anti-proliferation and G1 arrest effect of wogonin on HCT116 cells was associated with deregulation of Wnt/beta-catenin signaling pathway.
References: Toxicology. 2013 Oct 4; 312:36-47; Neurol Sci. 2015 Jul; 36(7):1181-8.
Related CAS: 51059-44-0 (Wogonoside)
Chemical Name: 4H-1-Benzopyran-4-one, 5, 7-dihydroxy-8-methoxy-2-phenyl-
InChi Key: XLTFNNCXVBYBSX-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8, 17, 19H, 1H3
SMILES Code: O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13
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