sh5-07

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	50mg
Item no.	V1272-50mg
CASRN	1456632-41-9
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V1272CAS #:1456632-41-9Purity >=98% Description: SH5-07 (SH5 07; SH-507; SH5-07), a structural analog of BP-1-102, is a novel, potent and hydroxamic acid-based STAT3 inhibitor with potential antitumor activity. It shows potent anti-proliferative activity in vitro and high in vivo antitumor efficacy against human glioma and breast cancer models. SH5-07 dose-dependently inhibits Stat3 activity with an IC50 of 3.9+/-0.6 uM in in vitro assay. It preferentially inhibits Stat3: Stat3 DNA-binding activity, ahead of inhibiting Stat1:Stat3 activity, with minimal effects on Stat1:Stat1 activity. SH5-07 binds Stat3, disrupts Stat3 association with growth factor receptor, and thereby inhibits Stat3 phosphorylation. References: Cancer Res. 2016 Feb 1; 76(3):652-63.
Molecular Weight (MW)	625.61
Formula	C29H28F5N3O5S
CAS No.	1456632-41-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (159.8 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (159.8 mM)
SMILES	O=C(NO)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1
Synonyms	SH5 07; SH507; SH5-07

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Amount: 50mg

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Delivery expected until 6/6/2024