gant61

Item no.	V1337-5mg
Manufacturer	InvivoChem LLC
CASRN	500579-04-4
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	500579-04-4
Available
Description	InvivoChem Cat #:V1337CAS #:500579-04-4Purity >=98% Description: GANT61 (GANT 61; nsc 136476; GANT-61; nsc-136476) is a novel and potent small-molecule inhibitor for GLI1 (glioma-associated oncogene 1) and GLI2-induced transcription with potential anticancer activity. It inhibits the hedgehog pathway with an IC50 of 5 uM in GLI1 expressing HEK293T cell, and also displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 exerts its effect by preventing DNA binding. It has been demonstrated to induce cell death against Ewing's sarcoma family tumor (ESFT) cell lines in a dose-dependent manner. Description: References: Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8455-60; Int J Cancer. 2013 Apr 1; 132(7):1516-24. References:
Molecular Weight (MW)	429.6
Formula	C27H35N5
CAS No.	500579-04-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 12 mg/mL (27.9 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	5% DMSO+95% Corn oil: 30 mg/mL
Synonyms	NSC 136476; GANT61; nsc136476; GANT 61; nsc 136476; GANT-61; nsc-136476;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 14 days

Compare

Add to wishlist

Get an offer