GANT61

Item no.	V1337-500mg
Manufacturer	InvivoChem LLC
CASRN	500579-04-4
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1337CAS #:500579-04-4Purity >=98% Description: GANT61 (GANT 61; nsc 136476; GANT-61; nsc-136476) is a novel and potent small-molecule inhibitor for GLI1 (glioma-associated oncogene 1) and GLI2-induced transcription with potential anticancer activity. It inhibits the hedgehog pathway with an IC50 of 5 uM in GLI1 expressing HEK293T cell, and also displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 exerts its effect by preventing DNA binding. It has been demonstrated to induce cell death against Ewing's sarcoma family tumor (ESFT) cell lines in a dose-dependent manner. Description: References: Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8455-60; Int J Cancer. 2013 Apr 1; 132(7):1516-24. References:
Molecular Weight (MW)	429.6
Formula	C27H35N5
CAS No.	500579-04-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 12 mg/mL (27.9 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	5% DMSO+95% Corn oil: 30 mg/mL
Synonyms	NSC 136476; GANT61; nsc136476; GANT 61; nsc 136476; GANT-61; nsc-136476;

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Amount: 500 mg

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