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conivaptan-hcl

conivaptan-hcl

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	500mg
Item no.	V1484-500mg
CASRN	168626-94-6
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V1484CAS #:168626-94-6Purity >=98% Description: Conivaptan HCl (formerly known as YM-087; YM087; YM 087, trade name Vaprisol), the hydrochloride salt of Conivaptan, is an orally bioavailable and non-peptide antagonist of vasopressin V1A and V2 receptors with anti-hypernatremic activity. It inhibits rat liver V1A receptor and rat kidney V2 receptor with Ki values of 0.48 and 3.04 nM, respectively. Conivaptan has been approved in 2004 for use in the treatment of euvolemic and hypervolemic hyponatremia, specifically, for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH), and there is some evidence it may be effective in heart failure. Conivaptan inhibits two of the three subtypes of the vasopressin receptor (V1a and V2). Description: References: Eur J Pharmacol. 2005 Jan 10; 507(1-3):145-51; J Hepatol. 2003 Jun; 38(6):755-61. References: Related CAS#: 210101-16-9(free base)
Molecular Weight (MW)	535.04
Formula	C32H26N4O2.HCl
CAS No.	168626-94-6 (HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 107 mg/mL (200 mM)
	Water: < 1 mg/mL
	Ethanol: 7 mg/mL (13.1 mM)
Other info	Chemical Name: N-[4-(2-Methyl-4, 5-dihydro-3H-imidazo[4, 5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride InChi Key: BTYHAFSDANBVMJ-UHFFFAOYSA-N InChi Code: InChI=1S/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22; /h2-18H, 19-20H2, 1H3, (H, 33, 34)(H, 35, 37); 1H SMILES Code: O=C(NC1=CC=C(C(N2CCC(NC(C)=N3)=C3C4=CC=CC=C42)=O)C=C1)C5=CC=CC=C5C6=CC=CC=C6.[H]Cl
Synonyms	YM-087 HCl; Conivaptan; Conivaptan; YM 087; YM087; Vaprisol

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Amount: 500mg

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Delivery expected until 6/6/2024