am251

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	500mg
Item no.	V1517-500mg
CASRN	183232-66-8
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V1517CAS #:183232-66-8Purity >=98% Description: AM251 is a potent and selective cannabinoid (CB) receptor antagonist that blocks the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. AM251 improves recognition memory in rats and produces nocifensive behavior via activation of ERK signaling pathway. Moreover, AM251 alters mitochondrial physiology via proteolytic degradation of ERRalpha and attenuates mechanical allodynia and thermal hyperalgesia after burn injury. Description: References: Basic Clin Pharmacol Toxicol. 2004 Feb; 94(2):73-8; Physiol Behav. 2004 Oct 15; 82(5):863-9. References:
Molecular Weight (MW)	555.24
Formula	C22H21Cl2IN4O
CAS No.	183232-66-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 40 mg/mL (72.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 8 mg/mL
Synonyms	AM251; AM 251; AM-251.

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Amount: 500mg

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Delivery expected until 6/6/2024