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BMS-265246

BMS-265246

Item no.	V1554-5mg
Manufacturer	InvivoChem LLC
CASRN	582315-72-8
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	582315-72-8
Available
Description	InvivoChem Cat #:V1554CAS #:582315-72-8Purity >=98% Description: BMS-265246 is a novel, potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4. BMS265246 inhibited the Cdk4/cycD activity and prevented A2780 Cytox (IC50 = 0.23 uM and 0.76 uM). In HCT-116 cells, BMS-265246 blocked the cell proliferation (EC50= 0.293 um—0.492 um). Following the treatment of BMS-265246, low DNA intensity, large round nuclei and 4N DNA content were observed in the dominant cell population –G2 arrested cells. References: Bioorg Med Chem Lett. 2003 Jul 21; 13(14):2405-8; Mol Cancer Ther. 2011 Feb; 10(2):242-54.
Molecular Weight (MW)	345.34
Formula	C18H17F2N3O2
CAS No.	582315-72-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 20 mg/mL (57.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
Synonyms	BMS265246; BMS-265246; BMS 265246; (4-butoxy-1H-pyrazolo[3, 4-b]pyridin-5-yl)(2, 6-difluoro-4-methylphenyl)methanone

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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