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BMS-265246

BMS-265246

Item no.	V1554-50mg
Manufacturer	InvivoChem LLC
CASRN	582315-72-8
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1554CAS #:582315-72-8Purity >=98% Description: BMS-265246 is a novel, potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4. BMS265246 inhibited the Cdk4/cycD activity and prevented A2780 Cytox (IC50 = 0.23 uM and 0.76 uM). In HCT-116 cells, BMS-265246 blocked the cell proliferation (EC50= 0.293 um—0.492 um). Following the treatment of BMS-265246, low DNA intensity, large round nuclei and 4N DNA content were observed in the dominant cell population –G2 arrested cells. References: Bioorg Med Chem Lett. 2003 Jul 21; 13(14):2405-8; Mol Cancer Ther. 2011 Feb; 10(2):242-54.
Molecular Weight (MW)	345.34
Formula	C18H17F2N3O2
CAS No.	582315-72-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 20 mg/mL (57.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
Synonyms	BMS265246; BMS-265246; BMS 265246; (4-butoxy-1H-pyrazolo[3, 4-b]pyridin-5-yl)(2, 6-difluoro-4-methylphenyl)methanone

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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