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Description: SBE 13 HCl is a novel, potent and selective PLK1 inhibitor with IC50 of 200 pM, and shows > 4000-fold selectivity over Aurora A kinase, Plk2 and Plk3. SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells.
References: Cell Cycle. 2010 Feb 15; 9(4):761-73; Oncotarget. 2014 Apr 30; 5(8):2263-75.
Related CAS: 775294-82-1 (free base)
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