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Bicalutamide (Casodex; ICI-176334)

Bicalutamide (Casodex; ICI-176334)

Item no.	V1758-250mg
Manufacturer	InvivoChem LLC
CASRN	90357-06-5
Amount	250 mg
Quantity options	10 g 1 g 2 g 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	90357-06-5
Available
Description	InvivoChem Cat #:V1758CAS #:90357-06-5Purity >=98% Description: Bicalutamide (also known as ICI-176334; CDX; trade names: Casodex in the USA and Cosudex in other countries), a marketed drug for treating PC (prostate cancer), is a potent, synthetic, nonsteroidal androgen receptor (AR) antagonist with IC50 of 0.16 uM in LNCaP/AR(cs)cell line. Bicalutamide inhibits the growth of prostate cancer cells which overexpress androgen receptor by directly binding to AR then mediates androgen-mediated gene transcription. Bicalutamide directly binds to androgen receptor with Ki value of 12.5uM. In prostate cancer cells, bicalutamide impairs DNA binding and nuclear localization. Bicalutamide and MDV3100 significantly inhibited R1881-induced VP16-AR–mediated transcription in HepG2 cells with an IC50 value of 0.2 uM. References: Cancer Res. 2012 Mar 15; 72(6):1494-503; Int J Oncol. 2012 Aug; 41(2):425-32.
Molecular Weight (MW)	430.37
Formula	C18H14F4N2O4S
CAS No.	90357-06-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 86 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 5 mg/mL (11.6 mM)
Solubility (In vivo)	Chemical Name: N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide InChi Key: LKJPYSCBVHEWIU-UHFFFAOYSA-N InChi Code: InChI=1S/C18H14F4N2O4S/c1-17(26, 10-29(27, 28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20, 21)22/h2-8, 26H, 10H2, 1H3, (H, 24, 25) SMILES Code: O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C(C)(O)CS(=O)(C2=CC=C(F)C=C2)=O
Synonyms	ICI-176334; ICI 176334; ICI-176334; ICI176334; CDX. US trade name: Casodex. Foreign trade name: Cosudex.

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Amount: 250 mg

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