« Back
Home /
Bicalutamide (Casodex; ICI-176334)

Bicalutamide (Casodex; ICI-176334)

Item no.	V1758-5g
Manufacturer	InvivoChem LLC
CASRN	90357-06-5
Amount	5 g
Quantity options	10 g 1 g 250 mg 2 g 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1758CAS #:90357-06-5Purity >=98% Description: Bicalutamide (also known as ICI-176334; CDX; trade names: Casodex in the USA and Cosudex in other countries), a marketed drug for treating PC (prostate cancer), is a potent, synthetic, nonsteroidal androgen receptor (AR) antagonist with IC50 of 0.16 uM in LNCaP/AR(cs)cell line. Bicalutamide inhibits the growth of prostate cancer cells which overexpress androgen receptor by directly binding to AR then mediates androgen-mediated gene transcription. Bicalutamide directly binds to androgen receptor with Ki value of 12.5uM. In prostate cancer cells, bicalutamide impairs DNA binding and nuclear localization. Bicalutamide and MDV3100 significantly inhibited R1881-induced VP16-AR–mediated transcription in HepG2 cells with an IC50 value of 0.2 uM. References: Cancer Res. 2012 Mar 15; 72(6):1494-503; Int J Oncol. 2012 Aug; 41(2):425-32.
Molecular Weight (MW)	430.37
Formula	C18H14F4N2O4S
CAS No.	90357-06-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 86 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 5 mg/mL (11.6 mM)
Solubility (In vivo)	Chemical Name: N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide InChi Key: LKJPYSCBVHEWIU-UHFFFAOYSA-N InChi Code: InChI=1S/C18H14F4N2O4S/c1-17(26, 10-29(27, 28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20, 21)22/h2-8, 26H, 10H2, 1H3, (H, 24, 25) SMILES Code: O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C(C)(O)CS(=O)(C2=CC=C(F)C=C2)=O
Synonyms	ICI-176334; ICI 176334; ICI-176334; ICI176334; CDX. US trade name: Casodex. Foreign trade name: Cosudex.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5 g

available

Delivery expected until 11/6/2025

Express Delivery: Save 14 days

Compare

Add to wishlist

Get an offer