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ddr1-in-1

ddr1-in-1

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	50mg
Item no.	V1882-50mg
CASRN	1449685-96-4
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V1882CAS #:1449685-96-4Purity >=98% Description: DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, and is about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. References: ACS Chem Biol. 2013 Oct 18; 8(10):2145-50.
Molecular Weight (MW)	552.59
Formula	C30H31F3N4O3
CAS No.	1449685-96-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (181 mM)
	Water: < 1 mg/mL
	Ethanol: 4 mg/mL (7.2 mM)
Other info	Chemical Name: 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-(2-oxoindolin-5-yloxy)phenyl)-3-(trifluoromethyl)benzamide SMILES: FC(C1=CC(C(NC2=CC=C(C(OC3=CC(C4)=C(C=C3)NC4=O)=C2)C)=O)=CC=C1CN5CCN(CC)CC5)(F)F
Synonyms	DDR1-IN-1; DDR1-IN 1; DDR1-IN1

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Amount: 50mg

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Delivery expected until 6/6/2024