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xe991-hcl

xe991-hcl

Item no.	V21023-25mg
Manufacturer	InvivoChem LLC
CASRN	122955-13-9
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V21023CAS #:122955-13-9Purity >=98% Description: XE991 diHCl (LS190926) is a novel, potent and selective blocker of KCNQ (Kv7) voltage-gated potassium channels. XE991 blocks KCNQ2+3/M-currents (IC50 = 0.6-0.98 uM) and KCNQ1 homomeric channels (IC50 = 0.75 uM) but is less potent against KCNQ1/minK channels (IC50 = 11.1 uM). References: 1. WangHS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecularcorrelates of the M-channel. Science. 1998 Dec 4; 282(5395):1890-3. 2. ZaczekR, et al. Two new potent neurotransmitter release enhancers, 10, 10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and10, 10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison tolinopirdine. J Pharmacol Exp Ther. 1998 May; 285(2):724-30. 3. Greene DL, Kang S, Hoshi N. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits. J Pharmacol Exp Ther. 2017 May 8. pii: jpet.117.241679.

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Amount: 25mg

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