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eplerenone

eplerenone

Item no.	V2139-5mg
Manufacturer	InvivoChem LLC
CASRN	107724-20-9
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	107724-20-9
Available
Description	InvivoChem Cat #:V2139CAS #:107724-20-9 Purity >=98% Description: Eplerenone (also known as CGP 30083, Inspra, SC-66110) is a potent and selective mineralocorticoid receptor antagonist with an IC50 of 0.36 uM, it blocks the action of aldosterone, used to control high blood pressure. Eplerenone inhibits upregulated phosphorylation of PKCepsilon, MAP kinase, and p90RSK in Dahl salt-sensitive hypertensive (DS) rats. Eplerenone increases downregulated endothelial nitric oxide synthase mRNA in Dahl salt-sensitive hypertensive (DS) rats. Eplerenone administration results in significant improvement in glomerulosclerosis and urinary protein in DS rats. Eplerenone (200 mg/kg/day) administration significantly decreases systolic and diastolic blood pressure by 12% and 11%, respectively, compared with untreated mice. References: Hypertension. 2005 Apr; 45(4):538-44; J Cardiovasc Pharmacol. 2003 Jun; 41(6):955-63; Circulation. 2001 Jul 24; 104(4):467-72.
Molecular Weight (MW)	414.49
Formula	C24H30O6
CAS No.	107724-20-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 4 mg/mL (9.7 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: methyl (4aS, 4bR, 5aR, 6aS, 7R, 9aS, 9bR, 10R)-4a, 6a-dimethyl-2, 5'-dioxo-2, 4, 4a, 4', 5a, 5', 6, 6a, 8, 9, 9a, 9b, 10, 11-tetradecahydro-3H, 3'H-spiro[cyclopenta[1, 2]phenanthro[4, 4a-b]oxirene-7, 2'-furan]-10-carboxylate InChi Key: JUKPWJGBANNWMW-VWBFHTRKSA-N InChi Code: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16, 2)12-17-24(19, 21)29-17/h10, 15-17, 19H, 4-9, 11-12H2, 1-3H3/t15-, 16+, 17-, 19+, 21+, 22+, 23-, 24-/m1/s1 SMILES Code: C[C]12CCC(C=C1C[CH](C(OC)=O)[CH]3[C]24[CH](C[C]5(C)[CH]3CC[C]56CCC(O6)=O)O4)=O
Synonyms	CGP-30083, SC-66110; CGP30083; CGP 30083; SC 66110; SC66110; Inspra; Selara

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Amount: 5 mg

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