« Back
Home /
Eplerenone (Epoxymexrenone; CGP 30083)

Eplerenone (Epoxymexrenone; CGP 30083)

Item no.	V2139-100mg
Manufacturer	InvivoChem LLC
CASRN	107724-20-9
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2139CAS #:107724-20-9 Purity >=98% Description: Eplerenone (also known as CGP 30083, Inspra, SC-66110) is a potent and selective mineralocorticoid receptor antagonist with an IC50 of 0.36 uM, it blocks the action of aldosterone, used to control high blood pressure. Eplerenone inhibits upregulated phosphorylation of PKCepsilon, MAP kinase, and p90RSK in Dahl salt-sensitive hypertensive (DS) rats. Eplerenone increases downregulated endothelial nitric oxide synthase mRNA in Dahl salt-sensitive hypertensive (DS) rats. Eplerenone administration results in significant improvement in glomerulosclerosis and urinary protein in DS rats. Eplerenone (200 mg/kg/day) administration significantly decreases systolic and diastolic blood pressure by 12% and 11%, respectively, compared with untreated mice. References: Hypertension. 2005 Apr; 45(4):538-44; J Cardiovasc Pharmacol. 2003 Jun; 41(6):955-63; Circulation. 2001 Jul 24; 104(4):467-72.
Molecular Weight (MW)	414.49
Formula	C24H30O6
CAS No.	107724-20-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 4 mg/mL (9.7 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: methyl (4aS, 4bR, 5aR, 6aS, 7R, 9aS, 9bR, 10R)-4a, 6a-dimethyl-2, 5'-dioxo-2, 4, 4a, 4', 5a, 5', 6, 6a, 8, 9, 9a, 9b, 10, 11-tetradecahydro-3H, 3'H-spiro[cyclopenta[1, 2]phenanthro[4, 4a-b]oxirene-7, 2'-furan]-10-carboxylate InChi Key: JUKPWJGBANNWMW-VWBFHTRKSA-N InChi Code: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16, 2)12-17-24(19, 21)29-17/h10, 15-17, 19H, 4-9, 11-12H2, 1-3H3/t15-, 16+, 17-, 19+, 21+, 22+, 23-, 24-/m1/s1 SMILES Code: C[C]12CCC(C=C1C[CH](C(OC)=O)[CH]3[C]24[CH](C[C]5(C)[CH]3CC[C]56CCC(O6)=O)O4)=O
Synonyms	CGP-30083, SC-66110; CGP30083; CGP 30083; SC 66110; SC66110; Inspra; Selara

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 29 days

Compare

Add to wishlist

Get an offer