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Milnacipran HCl

Milnacipran HCl

Item no.	V2399-10mg
Manufacturer	InvivoChem LLC
CASRN	101152-94-7
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	101152-94-7
Available
Description	InvivoChem Cat #:V2399CAS #:101152-94-7 Purity >=98% Description: Milnacipran HCl, a medication used in the clinical treatment of fibromyalgia, is a potent inhibitor of both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. Milnacipran is mainly excreted in the urine as the parent and glucoronide (> 80%), and only a small fraction (< 10%) is metabolized via N-de-ethylation by the CYP3A4 enzyme. Milnacipran at high concentration can inhibit certain ligand-gated ion-channel (LGIC) receptors, including NMDA, 5-HT3A and nACh receptors, with IC50 of 58.4 uM, 185 uM, 14.3 uM. References: Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1346-9; Psychopharmacology (Berl). 2004 Sep; 175(2):241-6; Psychopharmacology (Berl). 2002 Jul; 162(3):323-32. Related CAS #: 101152-94-7 (HCl) 92623-85-3 (free base) 175131-60-9 (Levomilnacipran HCl)
Molecular Weight (MW)	282.81
Formula	C15H22N2O.HCl
CAS No.	101152-94-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 57 mg/mL (201.5 mM)
	Water: 57 mg/mL (201.5 mM)
	Ethanol: 57 mg/mL (201.5 mM)
Other info	Chemical Name: (1R, 2S)-2-(aminomethyl)-N, N-diethyl-1-phenylcyclopropane-1-carboxamide hydrochloride InChi Key: XNCDYJFPRPDERF-PBCQUBLHSA-N InChi Code: InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12; /h5-9, 13H, 3-4, 10-11, 16H2, 1-2H3; 1H/t13-, 15+; /m1./s1 SMILES Code: O=C([C]1(C2=CC=CC=C2)[CH](CN)C1)N(CC)CC
Synonyms	Levomilnacipran, F-2207, Ixel, Savella, Dalcipran, Toledomin

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 10 mg

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