me-344

Description: ME-344, an active metabolite of NV-128, is a novel flavonoid-based small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells. In pre-clinical studies, ME-344 has shown tenfold more anti-tumor activity than NV-128.

References: Lim SC, Carey KT, McKenzie M. Anti-cancer analogues ME-143 and ME-344 exerttoxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase(Complex I). Am J Cancer Res. 2015 Jan 15; 5(2):689-701. eCollection 2015. PubMedPMID: 25973307; PubMed Central PMCID: PMC4396027.