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mln-4760

mln-4760

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	25mg
Item no.	V25708-25mg
CASRN	305335-31-3
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V25708CAS #:305335-31-3Purity >=98% Description: MLN-4760 is a novel, potent and selective human angiotensin-converting (ACE2) inhibitor with IC50 of 0.44 nM and with excellent selectivity (> 5000-fold) versus related enzymes including human testicular ACE (IC50, > 100 uM) and bovine carboxypeptidase A (CPDA; IC50, 27 uM). In huMNCs, MLN-4760-B detected 63% ACE2 with 28-fold selectivity over ACE. References: 1. DalesNA, et al. Substrate-based design of the first class ofangiotensin-converting enzyme-related carboxypeptidase (ACE2)inhibitors. J Am Chem Soc. 2002 Oct 9; 124(40):11852-3. 2. JoshiS, et al. Angiotensin converting enzyme versus angiotensin convertingenzyme-2 selectivity of MLN-4760 and DX600 in human and murine bonemarrow-derived cells. Eur J Pharmacol. 2016 Mar 5; 774:25-33. 3. BennionDM, et al. Activation of the Neuroprotective Angiotensin-ConvertingEnzyme 2 in Rat Ischemic Stroke. Hypertension. 2015 Jul; 66(1):141-8.

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Amount: 25mg

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Delivery expected until 7/4/2024