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S1RA (E-52862) HCI

S1RA (E-52862) HCI

Item no.	V28975-25mg
Manufacturer	InvivoChem LLC
CASRN	NULL
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V28975CAS #:1265917-14-3 (HCl)Purity >=98% Description: S1RA HCl (also known as E-52862 HCl) is a potent and selective sigma-1 receptor(sigma1R, Ki=17 nM) antagonist, showed good selectivity against sigma2R (Ki > 1000 nM). E-52862 showed high activity in the mouse capsaicin model of neurogenic pain, emerged as the most interesting candidate. In addition, compound 28 exerted dose-dependent antinociceptive effects in several neuropathic pain models. This, together with its good physicochemical, safety, and ADME properties, led compound 28 to be selected as clinical candidate. References: Br J Pharmacol. 2012 Aug; 166(8):2289-306; J Med Chem. 2012 Oct 11; 55(19):8211-24. Related CAS#: 878141-96-9 (free base); 1265917-14-3 (HCl)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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