« Back
Home /
S1RA (E-52862) HCI

S1RA (E-52862) HCI

Item no.	V28975-5mg
Manufacturer	InvivoChem LLC
CASRN	NULL
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1265917-14-3
Available
Description	InvivoChem Cat #:V28975CAS #:1265917-14-3 (HCl)Purity >=98% Description: S1RA HCl (also known as E-52862 HCl) is a potent and selective sigma-1 receptor(sigma1R, Ki=17 nM) antagonist, showed good selectivity against sigma2R (Ki > 1000 nM). E-52862 showed high activity in the mouse capsaicin model of neurogenic pain, emerged as the most interesting candidate. In addition, compound 28 exerted dose-dependent antinociceptive effects in several neuropathic pain models. This, together with its good physicochemical, safety, and ADME properties, led compound 28 to be selected as clinical candidate. References: Br J Pharmacol. 2012 Aug; 166(8):2289-306; J Med Chem. 2012 Oct 11; 55(19):8211-24. Related CAS#: 878141-96-9 (free base); 1265917-14-3 (HCl)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5 mg

available

Delivery expected until 7/3/2025

Express Delivery: Save 16 days

Compare

Add to wishlist

Recommend by mail