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Description: Geissoschizine methyl ether, a naturally occuring indole alkaloid extrated from Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist, and also a potent acetylcholinesterase (AChE) inhibitor.
References:
1. MatsumotoT, et al. In vitro identification of human cytochrome P450 isoformsinvolved in the metabolism of Geissoschizine methyl ether, an activecomponent of the traditional Japanese medicine Yokukansan. Xenobiotica.2016; 46(4):325-34.
2. NishiA, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is apotent serotonin ?A receptor agonist and candidate for amelioration ofaggressiveness and sociality by yokukansan. Neuroscience. 2012 Apr5; 207:124-36.
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