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Description: FD-IN-1 is a novel and potent factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase beta2 with IC50s of 7.7 and 6.5uM, respectively.
References: Design, Synthesis, and Preclinical Characterization of Selective Factor DInhibitors Targeting the Alternative Complement Pathway. J Med Chem.2019 May 9; 62(9):4656-4668.
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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