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Z-LEHD-FMK

Z-LEHD-FMK

Item no.	V4117-5mg
Manufacturer	InvivoChem LLC
CASRN	210345-04-3
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	210345-04-3
Available
Description	InvivoChem Cat #:V4117CAS #:210345-04-3Purity >=98% Description: Z-LEHD-FMK is a cell-permeable, specific, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. In HCT116 human colon cancer cell line and 293 human embryonic kidney cell line, Z-LEHD-FMK inhibited apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). These results suggested that TRAIL induced death through the mitochondrial pathway in some human cells. In a colony assay, Z-LEHD-FMK inhibited the reduction of colony growth of HCT116 induced by TRAIL. In normal human hepatocytes, Z-LEHD-FMK protected cells from TRAIL-induced apoptosis. These results suggested that a combination of Z-LEHD-FMK and TRAIL selectively killed cancer cells while protecting normal liver cells. Description: References: Res Vet Sci. 2016 Feb; 104:4-9. References: Related CAS#:524746-03-0 (TFA salt)
Molecular Weight (MW)	690.72
Formula	C32H43FN6O10
CAS No.	210345-04-3 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 10mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1, 4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate
Synonyms	Z-LEHD-FMK; Z-LEHD-FMK; Z LEHD-FMK; Z LEHD FMK; Z-LEHD FMK
SMILES Code	CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2

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Amount: 5 mg

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Delivery expected until 11/6/2025

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