« Back
Home /
Z-LEHD-FMK

Z-LEHD-FMK

Item no.	V4117-25mg
Manufacturer	InvivoChem LLC
CASRN	210345-04-3
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4117CAS #:210345-04-3Purity >=98% Description: Z-LEHD-FMK is a cell-permeable, specific, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. In HCT116 human colon cancer cell line and 293 human embryonic kidney cell line, Z-LEHD-FMK inhibited apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). These results suggested that TRAIL induced death through the mitochondrial pathway in some human cells. In a colony assay, Z-LEHD-FMK inhibited the reduction of colony growth of HCT116 induced by TRAIL. In normal human hepatocytes, Z-LEHD-FMK protected cells from TRAIL-induced apoptosis. These results suggested that a combination of Z-LEHD-FMK and TRAIL selectively killed cancer cells while protecting normal liver cells. Description: References: Res Vet Sci. 2016 Feb; 104:4-9. References: Related CAS#:524746-03-0 (TFA salt)
Molecular Weight (MW)	690.72
Formula	C32H43FN6O10
CAS No.	210345-04-3 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 10mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1, 4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate
Synonyms	Z-LEHD-FMK; Z-LEHD-FMK; Z LEHD-FMK; Z LEHD FMK; Z-LEHD FMK
SMILES Code	CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 25 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 7 days

Compare

Add to wishlist

Get an offer