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emricasan

emricasan

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	250mg
Item no.	V4486-250mg
CASRN	254750-02-2
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V4486CAS #:254750-02-2Purity >=98% Description: Emricasan (formerly also known as IDN-6556 and PF 03491390) is a potent, first-in-class and irreversible pan-caspase inhibitor. It is in clinical trials for the treatment of liver diseases. Emricasan decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. Emricasan facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral administration of Emricasan may lower aminotransferase activity in patients with chronic hepatitis C. Oral PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model. References: Liver Int. 2015 Mar; 35(3):953-66; Transl Stroke Res. 2017 Nov 4.; Surgery. 2011 Jul; 150(1):48-55.
	Name: Emricasan CAS#: 254750-02-2 Chemical Formula: C26H27F4N3O7 Exact Mass: 569.17851 Molecular Weight: 569.51 Elemental Analysis: C, 54.83; H, 4.78; F, 13.34; N, 7.38; O, 19.661
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Emricasan; PF 03491390; PF-03491390; PF03491390; IDN-6556; IDN6556; IDN 6556; Chemical Name: (S)-3-((S)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2, 3, 5, 6-tetrafluorophenoxy)pentanoic acid SMILES Code: O=C(O)C[CH](NC([CH](C)NC(C(NC1=CC=CC=C1C(C)(C)C)=O)=O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O

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Amount: 250mg

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Delivery expected until 6/6/2024