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ly-3130481

ly-3130481

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	10mg
Item no.	V4851-10mg
CASRN	1610802-47-5
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V4851CAS #:1610802-47-5Purity >=98% Description: LY3130481 (also known as CERC-611) is a novel and potent alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist t that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) gamma-8, it selective inhibits AMPA/TARP gamma-8 with an IC50 of 65 nM. LY3130481 is fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (?)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients. References: J Med Chem. 2016 May 26; 59(10):4753-68.
	Name: LY3130481 CAS#: 1610802-47-5 Chemical Formula: C19H18N4O3S Exact Mass: 382.11 Molecular Weight: 382.438 Elemental Analysis: C, 59.67; H, 4.74; N, 14.65; O, 12.55; S, 8.38
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: LY3130481; LY-3130481; LY 3130481; CERC-611; CERC611; CERC 611. IUPAC/Chemical Name: (S)-6-(1-(1-(5-(2-hydroxyethoxy)pyridin-2-yl)-1H-pyrazol-3-yl)ethyl)benzo[d]thiazol-2(3H)-one InChi Key: HLTKOFPQDKJCAN-LBPRGKRZSA-N InChi Code: InChI=1S/C19H18N4O3S/c1-12(13-2-4-16-17(10-13)27-19(25)21-16)15-6-7-23(22-15)18-5-3-14(11-20-18)26-9-8-24/h2-7, 10-12, 24H, 8-9H2, 1H3, (H, 21, 25)/t12-/m0/s1 SMILES Code: O=C1SC2=CC([CH](C3=NN(C4=NC=C(OCCO)C=C4)C=C3)C)=CC=C2N1

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Amount: 10mg

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Delivery expected until 6/6/2024