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litronesib

litronesib

Item no.	V4905-10mg
Manufacturer	InvivoChem LLC
CASRN	910634-41-2
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	910634-41-2
Available
Description	InvivoChem Cat #:V4905CAS #:910634-41-2Purity >=98% Description: Litronesib (formerly also known as LY2523355) is a novel, potent and selective inhibitor of the kinesin-related motor protein Eg5 with potential anticancer activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). References: Mol Cancer Ther. 2015 Nov; 14(11):2463-72.
	Name: Litronesib CAS#: 910634-41-2 Chemical Formula: C23H37N5O4S2 Exact Mass: 511.2287 Molecular Weight: 511.70098 Elemental Analysis: C, 53.99; H, 7.29; N, 13.69; O, 12.51; S, 12.53
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: LY2523355; LY-2523355; LY 2523355; KF89617; KF-89617; KF 89617; Eg5 KinesinRelated Motor Protein Inhibitor . IUPAC/Chemical Name: (R)-N-(5-((2-(ethylamino)ethylsulfonamido)methyl)-5-phenyl-4-pivaloyl-4, 5-dihydro-1, 3, 4-thiadiazol-2-yl)pivalamide. InChi Key: YVAFBXLHPINSIK-QHCPKHFHSA-N InChi Code: InChI=1S/C23H37N5O4S2/c1-8-24-14-15-34(31, 32)25-16-23(17-12-10-9-11-13-17)28(19(30)22(5, 6)7)27-20(33-23)26-18(29)21(2, 3)4/h9-13, 24-25H, 8, 14-16H2, 1-7H3, (H, 26, 27, 29)/t23-/m0/s1 SMILES Code: CC(C)(C)C(NC1=NN(C(C(C)(C)C)=O)[C](C2=CC=CC=C2)(CNS(=O)(CCNCC)=O)S1)=O

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Amount: 10mg

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Delivery expected until 7/31/2025

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