[Novoprotein] Recombinant Human Interleukin-7/IL-7 (C-6His)

Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide & a 152 amino acid mature protein. Human & mouse IL7 share 65% sequence identity in the mature region & both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT & PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, & differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

18, 4

Asp26-His177

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.