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Partner: Creative Biogene |Hölzel Diagnostika

Creative Biogene

Creative-Biogene

Creative Biogene - Genomics and Proteomics Reagents

Our US partner company Creative Biogene specializes in research reagents for the fields of genomics and proteomics. The company develops and produces unique tools for your biological and biomedical research. It also provides innovative services for academic and government research institutes. The pharmaceutical and biotechnology sectors are also among the main customers.

Our partner's diverse product portfolio includes transfected stable cell lines, cell lysates, virus particles, oligonucleotides, clones, enzymes and other laboratory equipment. Transfected stable cell lines with specific gene overexpression or knock-down are an extremely helpful tool in research. They are for example suitable for gene function analysis, target discovery, target validation, assay development and compound screening. However, generating stable cell lines is a time consuming and expensive process. That is why Creative Biogene offer a service for generating stable cell lines with a team of experts. These cell lines are generated by plasmid transfection / lentivirus transduction, selection of stable cells, colony removal, expression and functional screening as well as final validation of the construct expression by real-time qRT-PCR or Western blot analysis. A variety of stable cell lines have been successfully generated using these techniques, including gene knockout, gene overexpression, and gene knockdown cell lines.

Creative Biogene has established as an outstanding supplier for the development, production and purification of recombinant adenoviruses, as well as adeno-associated viruses (AAV) and lentiviruses for gene transport and knockdown. Adenoviruses have a wide range of hosts and can infect human and other mammalian cell lines or primary cells. There is no integration into the host genome and a high level of gene expression can be achieved in a very short time. Adeno-associated virus (AAV) is a small, replication-defective virus without envelope that can infect both dividing and non-dividing cells. AAV is an attractive candidate for gene transfer because it does not cause diseases and only induces a mild immune response. Lentiviruses are a powerful tool for delivering target genes to almost all types of mammalian cells and can integrate their own genome into that of the host cells. Stable and long-term gene expression can be obtained because of their high transduction efficiency and wide host range. Creative Biogene offers premade virus particles with high titers and guaranteed expression, as well as efficient transduction even with difficult-to-transfect cells / animal models.

In addition, Creative Biogene is a leading global customer service provider for scientific research and is committed to the development, manufacture and purification of recombinant adenoviruses, adeno-associated viruses (AAV) and lentiviruses for gene delivery and the degradation of genes. With over 20 years of experience, Creative Biogene specializes in providing gene delivery and gene knockdown services that cover the full range of biotechnological needs of early drug discovery and development.