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PARP1 Antibody (N-term) Blocking Peptide

PARP1 Antibody (N-term) Blocking Peptide

Item no.	ABC-BP6373a
Manufacturer	Abcepta
Amount	500 ug
Category	Oncology By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Citations	Tao,Z., Biochemistry 47 (21), 5804-5813 (2008)Gao,R., Mol. Cancer Ther. 7 (5), 1246-1250 (2008)Schreiber,V., EMBO J. 11 (9), 3263-3269 (1992)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Poly [ADP-ribose] polymerase 1,PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,PARP1,ADPRT,PPOL
Similar products	PARP1, PARP-1, PPOL, ADPRT, NAD(+) ADP-ribosyltransferase 1, Poly [ADP-ribose] polymerase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, ARTD1, ADP-ribosyltransferase diphtheria toxin-like 1
Available
Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP6373a was selected from the N-term region of human PARP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	PARP1 is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Gene Name	PARP1 {ECO:0000303\|PubMed:21680843, ECO:0000312\|HGNC:HGNC:270}
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 11/6/2025

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