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Cyclotraxin B (TFA)

Cyclotraxin B (TFA)

Item no.	HY-P1178A-100mg
Manufacturer	MedChem Express
Amount	100 mg
Quantity options	100 mg 1 ea
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Citations	[1]Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777. [2]Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89. [3]Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59.
Smiles	O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)N)C(O)=O)=O)=O)CCC(O)=O)=O)CCCCN)=O)([H])[C@H](O)C)=O)CC3=CC=C(C=C3)O)=O)=O)CCSC)=O.OC(C(F)(F)F)=O
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Trk Receptor
Shipping Temperature	Room temperature
Molecular Weight	1314.39
Product Description	Cyclotraxin B TFA is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B TFA inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B TFA has analgesic and anxiolytic effects[1][2][3].
Manufacturer - Research Area	Neurological Disease
Solubility	H2O
Manufacturer - Pathway	Neuronal Signaling; Protein Tyrosine Kinase/RTK
Isoform	TrkB
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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