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α-Casein (90-95)

α-Casein (90-95)

Item no.	HY-P1793-100mg
Manufacturer	MedChem Express
CASRN	83471-50-5
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	99.51
Citations	[1]Chruścińska E, et al. Binding ability of Cu2+ ions by opiate-like fragments of bovine casein. J Inorg Biochem. 1997 Apr;66(1):19-22.\|[2]Stępnik M, et al. The influence of bovine casein-derived exorphins on mast cells in rodents[J]. Revue française d'allergologie et d'immunologie clinique, 2002, 42(5): 447-453.\|[3]Kampa M, et al. Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors. Eur J Pharmacol. 1997 Sep 24;335(2-3):255-65.
Smiles	O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Biochemical Assay Reagents; Opioid Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	783.91
Product Description	α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC50= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer[1][2][3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	H2O
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling; Others
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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