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Gersizangitide

Gersizangitide

Item no.	HY-P3369-10mg
Manufacturer	MedChem Express
CASRN	2417491-82-6
Amount	10 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	98.05
Citations	[1]Fei X, et al. Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration. Arch Pharm Res. 2024 Jun;47(6):538-557.\|[2]Mirando AC, et al. A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling. JCI Insight. 2019 Feb 21;4(4):e122043.
Smiles	NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(C)C)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	AXT-107
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Akt; Tie; VEGFR
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Molecular Weight	2355.69
Product Description	Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis[1][2].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility	H2O: 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Isoform	Tie2
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-P3369-10mg-safety-datasheet.pdf