CD31

Item no.	HY-P3444-100mg
Manufacturer	MedChem Express
CASRN	161374-99-8
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	99.33
Citations	[1]Caligiuri G. Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019 Jul 1. 115(9):1425-1434.\|[2]Ling V, et al. Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31). Eur J Immunol. 1997 Feb. 27(2):509-14.\|[3]Bruggisser J, et al. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell Host Microbe. 2020 Jul 8. 28(1):69-78.e6.\|[4]Caligiuri G. CD31 as a Therapeutic Target in Atherosclerosis. Circ Res. 2020 Apr 24. 126(9):1178-1189. \|[5]Fornasa G, et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010 May 15. 184(10):5485-92.
Smiles	O=C([C@H]1N(CCC1)C([C@H](C)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CO)NC([C@H](CO)NC([C@H](C)NC([C@@H](NC([C@@H](N)CC(N)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)CC4=CNC5=CC=CC=C45
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	PECAM-1
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Bacterial; SHP2
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	2601.10
Product Description	CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation[1]-[5].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection; Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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Amount: 100 mg

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