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MAPK8IP1 Peptide - N-terminal region (AAP75255)

MAPK8IP1 Peptide - N-terminal region (AAP75255)

Item no.	AAP75255
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Neuroscience Neural Development By Cell Type Carcinoma Peptides & Proteins Western Blot Peptides By Organ Bladder Cancer
Type	Peptides
Format	Lyophilized
Applications	WB
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IB1,JIP1,JIP-1,PRKM8IP
Available
Manufacturer - Type	Blocking Peptide
Molecular Weight	78 kDa
Description	This is a synthetic peptide designed for use in combination with anti-MAPK8IP1 Antibody (ARP75255_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Gene symbol	MAPK8IP1
Protein size	711
Product format	Lyophilized powder
Reconstitution and storage	Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Description of target	This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Nucleotide accession_num	NM_005456.3
Protein accession_num	NP_005447.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AAP75255-datasheet.pdf

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Amount: 100 ug

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Delivery expected until 12/25/2025

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