Human IL-4 protein

Cytokine

IL-4

Lyophilized Human IL-4 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.129% HSA or BSA). Please prevent freeze-thaw cycles.

Interleukin-4(IL-4), an anti-inflammatory cytokine, plays significant role in pathogenesis of various diseases such as asthma, tumors, and HIV infections. IL-4 is firstly identified as a T cell-derived growth factor for B cells. IL-4 can mediate important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of vascular cell-adhesion molecule 1, promotion of eosinophil transmigration into the lungs, inhibition of T-lymphocyte apoptosis, and mucus hypersecretion. The role of IL-4 in the pathogenesis of asthma is supported by identification of polymorphisms linked to asthma in the IL-4 gene promoter and proteins involved in IL-4 signaling.

Lyophilized from sterile PBS, pH 7.4.

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL-4 protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.

Testing in progress

IL4, IL-4, IL-4B_cell stimulatory factor 1, B cell growth factor 1, BCGF1, BCGF-1, interleukin 4, binetrakin, BCDF, B-cell stimulatory factor 1, BSF1, BSF-1, IL4E12, interleukin-4, Lymphocyte stimulatory factor 1, MGC79403, pitrakinra