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Mouse Claudin-18.2 Protein, His,Twin-Streptavidin Tag (Detergent)

Mouse Claudin-18.2 Protein, His,Twin-Streptavidin Tag (Detergent)

Item no.	CL2-M5585-20ug
Manufacturer	ACROBiosystems
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Amino Acids
Type	Proteins
Format	Liquid
Specific against	Mouse (Murine, Mus musculus)
Host	Insect Cells
Conjugate/Tag	Unconjugated, Twin-Streptavidin
Purity	80%
Dry ice	Yes
NCBI	NP_001181850.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Claudin-18.2,CLDN18,Claudin-18
Shipping Condition	Dry ice
Available
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	N-10xHis & C-Twin-Streptavidin, Unconjugated
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	26.7 kDa
Manufacturer - Format	Liquid
Description	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Background	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Molecule	Claudin-18.2
Exp Region	Met 1 - Thr 203
Characteristics	This protein carries a polyhistidine tag at the N-terminus and a twin streptavidin tag at the C-terminus. The protein has a calculated MW of 26.7 kDa. The protein migrates as 40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Stability	● The product MUST be stored at -70°C or lower upon receipt ● -70°C for 12 months under sterile conditions.
Protectant	glycerol

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CL2-M5585-20ug-datasheet.pdf

CL2-M5585-20ug-safety-datasheet.pdf