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Human cytomegalovirus (strain Merlin) (HHV-5) Envelope protein H&L&UL128&UL130&UL131, Twin-Streptavidin Tag&His Tag (MALS verified)

Human cytomegalovirus (strain Merlin) (HHV-5) Envelope protein H&L&UL128&UL130&UL131, Twin-Streptavidin Tag&His Tag (MALS verified)

Item no.	ENN-V5283-500ug
Manufacturer	ACROBiosystems
Amount	500 ug
Quantity options	500 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens), Virus
Host	HEK293
Conjugate/Tag	Unconjugated, Streptavidin
Purity	90%
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Specificity	Human cytomegalovirus
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	N-Twin streptavidin \| Native \| C-10xHis \| Native, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	110.8 kDa (H&L) & 16.7 kDa (UL128) & 23.7 kDa (UL130) & 13.0 kDa (UL131)
Manufacturer - Format	Powder
Description	Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
Background	Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
Molecule	Envelope protein H&L&UL128&UL130&UL131
Exp Region	Ala 31 - Arg 278 & Arg 24 - Leu 719 (H&L) & Glu 28 - Gln 171 (UL128) & Ser 26 - Val 214 (UL130) & Gln 19 - Asn 129 (UL131)
Characteristics	This protein carries a twin streptavidin tag and polyhistidine tag. The protein has a calculated MW of 110.8 kDa (H&L) & 16.7 kDa (UL128) & 23.7 kDa (UL130) & 13.0 kDa (UL131). The protein migrates as 15 kDa, 35 kDa and 130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 2/19/2026

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