Recombinant Human Tumor necrosis factor receptor superfamily member 4/TNFRSF4/OX40

Ambient

Recombinant Human Tumor necrosis factor receptor superfamily member 4/TNFRSF4/OX40 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Leu29-Ala216) of Human OX40/TNFRSF4 fused with a IgG Fc tag at the N-terminus.

OX40, also termed CD134 & TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival & homeostasis of effector & memory T cells. OX40 is expressed on CD4+ & CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand & CD28-B7. The interaction between OX40 & OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, & survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function & differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, & T-cell-mediated inflammatory diseases.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.