Frizzled-7

Ambient

Recombinant Human Frizzled-7/FZD7 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (M1-L185) of Human Frizzled-7 fused with a polyhistidine tag at the C-terminus.

Frizzled-7 is a member of the Frizzled family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, it leads to the activation of disheveled proteins, nuclear accumulation of beta-catenin, inhibition of GSK-3 kinase & activation of Wnt target genes. Frizzled-7 is an unconventional G-protein-coupled glycoprotein receptors for Wnt proteins. Frizzled-7 contains a divergent N-terminal signal peptide, a conserved cysteine-rich domain, a variable-length linker region, a seven-pass transmembrane region, & a variable-length C-terminal cytoplasmic domain. Frizzled-7 is expressed in skeletal muscle to mediate muscle regeneration in response to Wnt-7a. It also expressed in embryonic stem cells, contributing to self-renewal signaling.